"The negative is comparable to the composer's score and the print to its performance. Each performance differs in subtle ways."Ansel Adams
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10 Acne Truths and Myths You Need To Know!
Reports show that over 90 percent of all adolescents and almost 25 percent of all adults are acne sufferers. And although acne affects about 50 percent of all adult women, acne does affect males and females worldwide, regardless of nationality.This ...
Men'S Skin Care
Believe it or not men have the same skin care issues as women. We usually do not hear about them, however, because the media tends not to focus on them as much in our society. Nonetheless, men get wrinkles and pimples, they have dry skin and they have ...
Natural Acne Treatments
At some point in your life you will probably suffer from acne. Almost everyone does. There has been a great deal of news about acne treatments recently with many claiming a combination of an acne prevention diet and some of the all natural acne ...
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In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
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CoralActives Acne Products Now Available at Kinney DrugsAlbany Times UnionCoralActives is proud to announce distribution of its Complete Acne Therapy System which includes their patent pending Retinol Exfoliating Cleanser, their patent pending 6% Benzoyl Peroxide Acne Serum, their 10% Benzoyl Peroxide Acne Cleansing Bar and ...and more » |
Technorati |
Fight Acne with Blue Light TherapyTechnoratiAcne is a frustrating condition that can strike people of all ages, gender, and race causing undue stress, embarrassment, and even low self-esteem. It's a debilitating condition that goes way beyond the aesthetic appearance of the skin. |
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