"When I was a kid I used to pray every night for a new bicycle. Then I realised that the Lord doesn't work that way so I stole one and asked Him to forgive me."Emo Philips
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Problems and Symptoms in Different Types of Diabetes
There are three different types of diabetes and each category has its own problems and symptoms that are specific to it. The first of these types of diabetes is Type 1, also known as "insulin dependent". This type of diabetes is called Juvenile diabetes ...
Pulling The Roots Of Disease
"Anybody who tells you that disease has only one cause, and that drugs and surgery are the solution, is DEAD WRONG." Dr. Ward Coleman, N.D. Unhealthy aging and diseases of the body systems (such as cancer, heart disease, diabetes, immune dysfunction, ...
What If Low-Carb Diets Can Cure Diabetes and Heart Diseases
Low-carb diets can be advantageous in increased body weight , heart disease and treatment of diabetes according to new clinical studies . Low carb diets still revolutionize the clinical practice of nutrition. Many scientists are now indicating low carb ...
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Clinical Question: In patients with hypertension is it safe to combine thiazide-type diuretic and beta-blocker?
Bottom Line: Studies suggest that the routine combined use of a thiazide with a beta-blocker should be questioned in the early management of hypertension, particularly in patients who are at increased risk of developing new-onset diabetes. In such patients, the increased risk of developing diabetes may exceed the benefit of blood pressure lowering.
Reference: J Hypertens. 2005 Oct;23(10):1777-1781
Study Design: Retrieve randomized control trials and meta-analysis
Synopsis: Recently published trials addressing the pharmacological management of hypertension have reported an increase in new-onset diabetes mellitus when comparing certain older and newer treatment regimens. Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified. So randomized control trials were retrieved that: (i) featured stepped treatment to manage hypertension; (ii) compared initial treatment using a thiazide or beta-blocker (older drug) with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or calcium antagonist (newer drug); (iii) assessed cardiovascular outcomes; (iv) reported new-onset diabetes; and (v) provided at least 1-year follow-up. A meta-analysis of available trials indicated that patients exposed to treatment regimens combining thiazides and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination of drugs (risk ratio for alternative therapy 0.81, 95% confidence interval 0.77-0.86). Current data cannot inform reliably about the risks associated with individual older drugs because of similar overall exposures in patients starting on newer and older drugs.
About the Author
A Certified Family Physician of the Philippine Academy of Family Physician and continue to complete the requirements for Continuing Medical Education in Family Practice. Also a member of the Philippine Medical Informatics Society, Philippine Occupational Health and Safety Inc., and Pangasinan Medical Society. Faculty Department of Physiology (Medicine) Lyseum- Northwestern University, Dagupan, Pangasinan, Faculty Medical Informatics Lyseu
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Diabetes researcher to be honoredSan Antonio ExpressBy Elaine Ayala Dr. Roberto Treviño, a San Antonio diabetes researcher and physician, will be honored Friday with the 2012 Benitia Humanitarian Award. Given by the Missionary Catechists of Divine Providence, a religious community based on the West Side ... |
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